Integra® Bilayer Wound Matrix (IBWM) is an advanced wound care device comprised of a porous matrix of cross-linked bovine tendon collagen and glycosaminoglycan and a semi-permeable polysiloxane (silicone layer).

The semi-permeable silicone membrane controls water vapor loss, provides a flexible adherent covering for the wound surface and adds increased tear strength to the device. The collagen-glycosaminoglycan biodegradable matrix provides a scaffold for cellular invasion and capillary growth.

To ensure best possible outcomes when using Integra® Bilayer Wound Matrix, the product must provide adequate coverage so that it conforms to and is in contact with the prepared wound bed. Integra® Bilayer Wound Matrix must also lay flat with no wrinkles, bubbles or gaps.

The below one-page guide includes:

    • Helpful formulas to calculate the number and size of sheets of IBWM
    • The approximate surface area covered per sheet
    • Estimated number of sheets needed per adult anatomy


Integra Bilayer Wound Matrix is indicated for the management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns, and skin tears) and draining wounds. The device is intended for one-time use.



  • This device should not be used in patients with known sensitivity to bovine collagen or chondroitin materials.
  • The device is not indicated for use in third-degree burns.


  • Do not resterilize. Discard all opened and unused portions of Integra Bilayer Wound Matrix.
  • Device is sterile if the package is unopened and undamaged. Do not use if the package seal is broken.
  • Discard device if mishandling has caused possible damage or contamination.
  • Integra Bilayer Wound Matrix should not be applied until excessive exudate, bleeding, acute swelling and infection are controlled.
  • Debridement or excision must be done thoroughly to remove any remaining necrotic tissue that may cause infection.
  • The following complications are possible with the use of wound dressings. If any of the conditions occur, the device should be removed: infection, chronic inflammation (initial application of wound dressings may be associated with transient, mild, localized inflammation), allergic reaction, excessive redness, pain or swelling.

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